Ibicuruzwa

.Imiterere yihariye ya molekile, igizwe nimpeta ya pyrrolidine ifite insimburangingo ya tert-butyl na Ethyl, hamwe nibikorwa bya karubasi, itanga ibintu bishimishije nibishobora gukoreshwa.Bimwe mubintu byambere byakoreshejwe (3R, 4S) -1-tert-Butyl 3- Ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ninshingano zayo nka chiral yubaka chiral muri synthesis.Kubaho kwa stereocenters kumwanya wa 3R na 4S bitanga amahirwe yo gukora molekile zigoye hamwe na stereochemie yihariye.Uru ruganda rushobora kuba ibikoresho byintangiriro yo guhuza ibice bitandukanye bya chiral, nkumuhuza wimiti, ibicuruzwa bisanzwe, hamwe nubuhinzi-mwimerere. Byongeye kandi, (3R, 4S) -1-tert-Butyl 3-ethyl 4-aminopyrrolidine-1, 3-dicarboxylate hydrochloride irashobora gukoreshwa nka catalizator cyangwa ligand muri catisime idasanzwe.Umugongo wa chiral pyrrolidine urashobora gutera chirality nigikorwa cya catalitiki kugirango uteze imbere guhitamo.Uru ruganda rushobora gukoreshwa muburyo butandukanye, nka synthesis ya enantioselective ya molekile kama, abahuza imiti, nibindi bikoresho bifite agaciro.Ikindi kandi, (3R, 4S) -1-tert-Butyl 3-ethyl 4-aminopyrrolidine-1,3- dicarboxylate hydrochloride ifite ibishoboka mubushakashatsi bwa chimie chimique.Imiterere yimiterere nimiterere ya chiral bituma iba igikoresho cyingirakamaro mugutezimbere abakandida ibiyobyabwenge.Uru ruganda rushobora gukoreshwa mugushakisha isano-yimikorere-ibikorwa, kunoza imiti ya farumasi, no kuzamura ibikorwa byibinyabuzima cyangwa guhitamo intego yibiyobyabwenge.Ikindi, (3R, 4S) -1-tert-Butyl 3-ethyl 4-aminopyrrolidine-1, 3-dicarboxylate hydrochloride irashobora kwinjizwa mumasomero yibintu kugirango isuzume byinshi muri gahunda yo kuvumbura ibiyobyabwenge.Aya masomero yububiko arashobora kugeragezwa kurwanya ibinyabuzima bitandukanye kugirango hamenyekane ibiyobora hamwe nabakandida ibiyobyabwenge.Imiterere ya chiral yuru ruganda irashobora kugira uruhare mukuvumbura imiti mishya ivura ifite imiti igezweho. Muri make, (3R, 4S) -1-tert-Butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ni byinshi. guhuza hamwe nibisabwa muri synthesis organique nubushakashatsi bwa farumasi.Ibiranga amatsinda ya chiral kandi ikora bituma agira inyubako yingirakamaro yo guhuza molekile zigoye no muri catisimike idasanzwe.Byongeye kandi, ubushobozi bwayo mubushakashatsi bwa chimie yubuvuzi na gahunda yo kuvumbura ibiyobyabwenge byerekana akamaro kayo mugutezimbere imiti mvaruganda.Ubwinshi nibintu byihariye bya (3R, 4S) -1-tert-Butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride bituma iba umutungo wingenzi mubijyanye na chimie organic, ubushakashatsi mu bya farumasi, no guteza imbere ibiyobyabwenge.