Ibicuruzwa

(3R, 4R) -1-. peptide na peptidomimetics kubikorwa bitandukanye.Bimwe mubintu nyamukuru bikoreshwa na Boc-4-methylproline ni nkitsinda ririnda amine ya aminide acide mugihe cya synthesis ya peptide.Kurinda amatsinda ni uguhindura byigihe gito bikingira amatsinda yihariye yimikorere ya molekile kugirango wirinde ingaruka zidakenewe mugihe cyogukora.Muri synthesis ya peptide, Boc-4-methylproline ikoreshwa nkitsinda ririnda itsinda rya amine, ryemerera guhitamo aside irike ya amine kugirango ikore peptide yifuzwa.Boc-4-methylproline nayo ikora nka chiral yubaka muri synthesis yibintu bitandukanye hamwe nibikorwa bya biologiya.Nka chiral compound, ifite stereocenter, ikabyara enantiomers ebyiri: (3R, 4R) -Boc-4-methylproline na (3S, 4S) -Boc-4-methylproline.Buri enantiomer irashobora kwerekana imiterere ya farumasi nubusabane hamwe nintego yibinyabuzima.Mugukoresha Boc-4-methylproline nkibikoresho bitangira, abahanga mu bya shimi barashobora kubona imiti myinshi ya chiral kugirango bavumbure kandi biteze imbere.Ikindi kandi, ibikomoka kuri Boc-4-methylproline byagaragaje ibikorwa bya mikorobe, virusi, na antikanseri.Izi mikoreshereze zakozweho ubushakashatsi ku bushobozi bwazo bwo kuvura indwara ziterwa na virusi zitandukanye, harimo bagiteri, virusi, na kanseri.Muguhindura imiterere ya Boc-4-methylproline no gusuzuma ibiyikomokaho, abashakashatsi barashobora gushakisha ubushobozi bwabo nkibintu byangiza cyangwa molekile ya scafold yo gushushanya imiti. Usibye kuba ikoreshwa muri synthesis ya peptide no guteza imbere ibiyobyabwenge, Boc-4-methylproline nayo ikoreshwa mukurema peptidomimetics.Peptidomimetics ni ibice bigana imiterere n'imikorere ya peptide ariko bikagira imbaraga zihamye hamwe na farumasi.Boc-4-methylproline irashobora kuba nk'inyubako yubaka mugushushanya no guhuza peptidomimetics, bigatuma habaho iterambere ryubuvuzi bushya hamwe na bioavailability hamwe nintego yihariye. Muri make, (3R, 4R) -1- (tert-Butoxycarbonyl) - 4-methylpyrrolidine-3-karubasi ya aside, cyangwa Boc-4-methylproline, ni uruganda rwinshi rukoreshwa cyane muri synthesis.Uruhare rwarwo nk'itsinda ririnda peptide ya peptide, kimwe n'imiterere ya chiral, bituma iba inyubako ntangarugero yo gukora peptide, peptidomimetics, hamwe na chiral.Ibikomoka kuri Boc-4-methylproline birakorwaho iperereza kubikorwa byabo bishobora kuba biologiya, birimo mikorobe, antiviral, na anticancer.Gukomeza ubushakashatsi no guhanga udushya mugukoresha Boc-4-methylproline mugushushanya ibiyobyabwenge bigira uruhare mugutezimbere imiti mishya yo kuvura no kunoza imyumvire yacu yibinyabuzima bigoye.