Ibicuruzwa

(3aR, 7aR) -4- (benzo [d] isothiazol-3-yl) octahydrospiro imiterere idasanzwe yiha imbaraga nyinshi zishobora gukoreshwa mubijyanye na chimie chimique no guteza imbere ibiyobyabwenge. Kimwe mubishobora gukoreshwa na BISO ni mukuvura indwara zifata ubwonko.Kubaho kwa benzo [d] isothiazol-3-yl moiety mu miterere yayo byerekana ko BISO ishobora kugira imikoranire na sisitemu yihariye ya neurotransmitter mu bwonko, nka glutamate cyangwa GABAergic.Izi sisitemu ya neurotransmitter igira uruhare mubibazo byinshi byubwonko nka epilepsy, guhangayika, hamwe nihungabana.Abashakashatsi bashoboraga gushakisha ubushobozi bwa BISO bwo guhindura ubwo buryo no guteza imbere imiti ivura indwara zandurira mu mitsi. Byongeye kandi, imiterere ya spiro ya BISO [isoindole-2,1-piperazin] ifite ubushobozi bwo gukoresha mu guteza imbere ibiyobyabwenge byibasiye imiti myinshi. intego yibinyabuzima.Imiterere yuburyo butatu hamwe no kuba hari amatsinda akora birashobora gukorana na reseptor cyangwa enzymes zihariye, bigatuma habaho imiti yimiti yatoranijwe kandi ikomeye.Abashakashatsi barashobora gukoresha iyi miterere yimiterere kugirango bateze imbere molekile ntoya yibasira reseptor zigira uruhare mu ndwara zitandukanye, nka kanseri, indwara zifata umutima, cyangwa indwara zanduza.Ikindi kandi, imiterere ya BISO ya spirocyclic ya BISO hamwe nitsinda rya amonium ryishyuza bituma ishobora kuba umukandida wa sisitemu yo gutanga ibiyobyabwenge.Kuba hari itsinda ryishyuzwa ryemerera gukora ionic complexes hamwe na molekile zishyizwe nabi, nka acide nucleic cyangwa proteyine.Izi nganda zirashobora korohereza itangwa rya molekile ya bioaktique mu ngirabuzimafatizo cyangwa ingirangingo zihariye, bikongera imbaraga zo kuvura mu gihe bigabanya ingaruka ziterwa na sisitemu. Birakwiye ko tumenya ko ibishoboka BISO ishobora gukoreshwa kandi bisaba ubushakashatsi n’iterambere.Imiterere yihariye itanga amahirwe kubashinzwe imiti yo gusuzuma imiti ya farumasi no kunoza ubushobozi bwayo bwo kuvumbura ibiyobyabwenge.Nkindi kintu cyose kijyanye n’imiti, ikoreshwa rya BISO rigomba kubahiriza protocole n’umutekano byashyizweho.Abashakashatsi bagomba kwitonda mugihe cyo guhuza, gutunganya, no kubika kugirango barinde umutekano kandi bagabanye ingaruka. Mu gusoza, (3aR, 7aR) -4- (benzo [d] isothiazol-3-yl) octahydrospiro [isoindole-2,1-piperazin ] -2-ium4-methylbenzenesulfonate, cyangwa BISO, isezeranya uburyo butandukanye bwo gukoresha imiti y’imiti no guteza imbere ibiyobyabwenge.Imiterere yihariye itanga amahirwe yo kuvumbura imiti mishya yo kuvura, uburyo bwo gutanga imiti igamije, no guhindura sisitemu ya neurotransmitter.Nyamara, ubushakashatsi bwimbitse burakenewe kugirango dusobanure neza ubushobozi bwabwo kandi tunoze imikoreshereze yabwo mubuvuzi.