Ibicuruzwa

Ifumbire (2S, 3R, 4R, 5S, 6R) -2- [4-Chloro-3- molekile igoye ifite imbaraga zishobora gukoreshwa mubijyanye na chimie na farumasi.Bimwe mubishobora gukoresha iyi nteruro ni mubijyanye na chimie chimique.Kubaho kwa chloro, ethoxybenzyl, na hydroxymethyl bitanga amahirwe yo gucukumbura imikoranire yikigo hamwe nintego yibinyabuzima no gusuzuma ubushobozi bwayo nkumuti wo kuvura.Imiterere y'uru ruganda yerekana ko ishobora kuba ifite ibikorwa bya farumasi cyangwa kwerekana ubushobozi bwo kuvumbura imiti.Abashakashatsi barashobora gukora ubushakashatsi butandukanye, harimo muri vitro no mu bushakashatsi bwa vivo, kugira ngo basuzume ibikorwa by’ibinyabuzima by’ibinyabuzima, uburyo bwo gukora, n’ubushobozi bwo kuvura.Ikomatanyirizo ryihariye rya stereochemie, hamwe n’ibishushanyo bya S na R, birashobora kugira uruhare mu bikorwa by’ibinyabuzima, bikagira molekile ishimishije yo gukomeza iperereza. Byongeye kandi, imiterere y’uru ruganda itanga amahirwe ya chimie organic chimique.Abashakashatsi barashobora gukoresha iyi nteruro nkibikoresho byo gutangiza synthesis ya molekile igoye cyangwa ibikomoka ku bicuruzwa bisanzwe.Muguhindura ibyatoranijwe mumikorere ya molekile ikora, abahanga mu bya shimi barashobora kubona ibice bifite imitungo yifuzwa, nko kunoza imiti, kongera imbaraga, cyangwa kugabanya uburozi.Kubaho kwa hydroxymethyl bifungura ibishoboka kugirango hahindurwe byinshi, nko kubihindura mumatsinda atandukanye yimirimo ikora, kwemerera gutegura isomero ritandukanye ryibintu bivangwa na progaramu zitandukanye.Ikindi kandi, ubushobozi bwikigo nkibice bya chiral byubaka muri sintezime idasanzwe. ntigomba kwirengagizwa.Kuba hari ibigo byinshi bya chiral muri molekile bituma habaho gutegura ibimera byiza bya enantiomerically, bifite akamaro kanini mubikorwa bya farumasi.Abahanga mu bya shimi barashobora gushakisha akamaro k’urwo ruganda mu kubaka molekile zigoye za chiral, zishobora gutuma havumburwa imiti mishya cyangwa guteza imbere uburyo bwa sintetike yuburyo bushya.Ni ngombwa kumenya ko gukorana n’uru ruganda bisaba ubuhanga mu gutunganya no guhuza molekile zikomeye.Abashakashatsi bagomba kwitonda kandi bagakurikiza protocole yumutekano ikwiye mugihe cyose, kuva synthesis kugeza kuranga no gufata.Mu ncamake, (2S, 3R, 4R, 5S, 6R) -2- [4-Chloro-3- (4-ethoxybenzyl) phenyl] -6- (hydroxymethyl) tetrahydro-2H-pyran-3,4,5-triol yerekana imbaraga zikomeye muri chimie chimique chimique, chimique organique chimique, hamwe na synthesis ya asimmetric.Imiterere yihariye hamwe na stereochemie yuguruye inzira yo gusobanukirwa nigikorwa cyibinyabuzima, gushushanya imiti mishya yo kuvura, no gushyiraho ingamba zifatika zo gukora molekile zikomeye.Gukomeza ubushakashatsi ku miterere y’uru ruganda no kubishyira mu bikorwa birashobora kugira uruhare mu iterambere ry’ibiyobyabwenge, sintezike y’imiti, no gusobanukirwa na sisitemu y’ibinyabuzima.