Ibicuruzwa

Poroteyine ya Cerebral dopamine neurotrophique (CDNF) yerekanwe kurinda inzira ya nigrostriatal dopaminergique iyo itanzwe nk'imitsi itera imbeba n'imbeba zerekana indwara ya Parkinson (PD).Muri ubu bushakashatsi, twasuzumye ingaruka za neuroprotective ya CDNF yatanzwe hamwe na recombinant adeno ifitanye isano na virusi (AAV) serotype 2 vector mu mbeba 6-hydroxydopamine (6-OHDA) ya PD.Inzira za AAV2 zifata CDNF, umurongo w'ingirabuzimafatizo ukomoka kuri neurotrophique (GDNF), cyangwa poroteyine y'icyatsi kibisi cyatewe muri striatum.Isesengura ryerekana poroteyine ryerekanye ko vector yacu ya AAV2 yatanze neza ingirabuzimafatizo ya neurotrophique mu bwonko kandi bituma habaho imvugo ndende ya poroteyine.Ibyumweru bibiri nyuma yo gutera inshinge za AAV2, 6-OHDA yatewe muri striatum yimbeba, bituma habaho kwangirika kwa sisitemu ya dopaminergique ya nigrostriatal.Umuti hamwe na AAV2-CDNF watumye igabanuka ryinshi rya amphetamine iterwa no guhinduranya impande zombi mugihe itanga gusa kurinda igice cya hydroxylase ya tirozine (TH) -immunoreactive selile muri imbeba substantia nigra pars compacta na TH-reaction fibre muri striatum.Ibyavuye muri ubu bushakashatsi bitanga ibindi bimenyetso byerekana ko CDNF ishobora gufatwa nk'ubuvuzi bwa Parkinson