Ibicuruzwa

2-.Uru ruganda rushobora gukoreshwa mubikorwa bitandukanye bya chimie yubuvuzi hamwe nuburyo bwo kuvumbura ibiyobyabwenge.Uburyo bumwe bwo gukoresha 2- (3-Formyl-4-hydroxy-phenyl) -4-methyl-thiazole-5-karubasi ya acide etyl ester ni nkibintu bitangira kuri synthesis yibiyobyabwenge.Imiterere yacyo irimo amatsinda yimikorere ashobora guhinduka no guhinduka, bigatuma abahanga mu bya shimi bavura binjiza ibintu bitandukanye kandi bagakora molekile zitandukanye zifite imiti yongerewe imiti.Muguhindura muburyo bunonosoye iki kigo, abashakashatsi barashobora kubyara isomero ryibikomoka kubikorwa byubushakashatsi bwibikorwa (SAR), bagasuzuma ingaruka zimpinduka zinyuranye kumbaraga zibiyobyabwenge, guhitamo, hamwe nimiti ya farumasi.Ikindi kandi, uru ruganda rushobora kwerekana ibikorwa byibinyabuzima ubwabyo , zishobora gushakishwa kubishobora kuvurwa.Kuba hari impeta ya thiazole hamwe na formyl hamwe na fenolike yerekana ko ishobora kugira antioxydeant na anti-inflammatory.Iyi mitungo ikunze gushakishwa mugutezimbere ibiyobyabwenge, kuko bishobora kugira uruhare mukurinda cyangwa kuvura indwara zitandukanye zijyanye na stress ya okiside hamwe nuburyo bwo gutwika ibintu, nkindwara zifata umutima cyangwa imitsi ya neurodegenerative. 2- (3-Formyl-4-hydroxy- phenyl) -4-methyl-thiazole-5-karubasi ya acide etyl ester irashobora kandi gukoreshwa mukwiga kubuza enzyme no guhuza enzyme-substrate.Enzymes igira uruhare runini muburyo butandukanye bwibinyabuzima kandi akenshi bigira uruhare mu ndwara.Mugushushanya ibigereranyo byuru ruganda no gukora iperereza ku mikoranire yabyo na enzymes zihariye, abashakashatsi barashobora kunguka ubumenyi mubikorwa byimisemburo kandi bagashobora kumenya intego nshya zibiyobyabwenge, cyane cyane mubihe bijyanye n’imikorere mibi ya enzymatique.Ikindi kandi, iyi nteruro ishobora gukoreshwa muburyo bwo gushushanya imiti ishingiye ku miterere. .Imiterere yihariye ituma ikwiranye nubushakashatsi bwa docking no kwerekana imiterere ya molekile, aho abashakashatsi bashobora guhanura uburyo bwo guhuza ibice hamwe na poroteyine zigamije kandi bagahindura imikoranire yabyo kugirango bongere umusaruro. Mu gusoza, 2- (3-Formyl-4-hydroxy-phenyl) -4-methyl-thiazole-5-karubasi ya acide ya Ethyl ester yerekana akamaro gakomeye muri chimie yubuvuzi no kuvumbura ibiyobyabwenge.Irashobora kuba intangiriro yingirakamaro yo guhuza ibice bishya hamwe na farumasi yongerewe imbaraga.Ikigeretse kuri ibyo, ibikorwa byacyo biologiya yibikorwa no gukorana na enzymes bituma iba umukandida ushimishije kugirango ukore ubushakashatsi mubikorwa byo kuvura.Gukomeza ubushakashatsi niperereza bizagaragaza ubushobozi bwuzuye bwuru ruganda mugutezimbere imiti mishya no gusobanukirwa inzira yibinyabuzima.