Ibicuruzwa

(1R, 2S, 5S) —6,6-DiMethyl-3-aza-bicylo imikoreshereze yingenzi yuru ruganda ni nka chiral yubaka muguhuza imiti ihuza imiti nibikoresho bikora bya farumasi (APIs).Imiterere yihariye yamagare hamwe na chirality bituma igira agaciro mugukora ibimera byiza bya enantiomerically.Mugushira iyi compound muri synthesis, chemiste barashobora kugenzura stereochemie no gukora imiti yihariye ya farumasi muri molekile zavuyemo.Ibi ni ingenzi cyane mugutezimbere ibiyobyabwenge, aho ibikorwa byibinyabuzima byifuzwa akenshi biterwa na gahunda ya molekile itandukanijwe. Byongeye kandi, (1R, 2S, 5S) —6,6-DiMethyl-3-aza-bicylo [3.1.0] hexane -2-karubasi ya aside yitwa Methyl ester hydrochloride ikoreshwa nkibibanziriza guhuza imiti ishingiye kuri quinuclidine.Inkomoko ya Quinuclidine yerekanye ibikorwa byinshi byibinyabuzima, harimo antipsychotic, anticonvulsant, na analgesic.Mugutangiza amatsinda yihariye yibikorwa, abahanga mu bya shimi barashobora guhindura imiti ya farumasi na farumasi, bikongerera ubushobozi bwo kuvura.Ikindi kandi, iyi nteruro isanga ikoreshwa nkigisubizo cyangwa umusemburo mubihinduka kama.Bitewe no kuba hariho amine yo mu rwego rwo hejuru hamwe n’imiterere yabangamiye cyane amatsinda ya methyl, irashobora kugira uruhare muburyo butandukanye bwimiti, nka amidation, alkylation, na cycloaddition reaction.Ubushobozi bwayo hamwe nubushobozi bwo gukora abahuza bigoye bituma iba igikoresho cyinshi muburyo bwo guhuza ibinyabuzima, bigatuma habaho gukora ibice bitandukanye byubaka. Muri make, (1R, 2S, 5S) —6,6-DiMethyl-3-aza-bicylo [3.1 .Chirality n'imiterere yihariye ituma habaho umusaruro wuzuye wa enantiomerically hamwe no guhuza imiti ishingiye kuri quinuclidine ifite imiti yihariye ya farumasi.Imyitwarire yacyo nayo ituma igira akamaro ningirakamaro muguhindura imiti itandukanye.Muri rusange, iyi nteruro igira uruhare runini mugutezimbere ubushakashatsi bwimiti no guteza imbere imiti mishya ivura.