Ibicuruzwa

1- (4-Methoxyphenyl) -7-oxo-6- [4- -3-karubasi ya acide etyl ester ni uruganda rukora imiti rwerekanye ubushobozi mubice bitandukanye bya chimie yubuvuzi no kuvumbura ibiyobyabwenge.Dore ibisobanuro byerekana imikoreshereze yamagambo agera kuri 300.Iyi nteruro, bakunze kwita etyl ester ikomoka kuri 1- (4-Methoxyphenyl) -7-oxo-6- [4- (2-oxopiperidin-1-yl) phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c] pyridine-3-karubasi ya acide, ni icyiciro cya pyrazolo [3,4-c] ibikomoka kuri pyridine.Izi nkomoko zashishikaje abantu kuvumbura ibiyobyabwenge bitewe nubushobozi bwabo mubice bitandukanye byo kuvura.Bimwe mubishobora gukoreshwa muribi bikoresho biri mubushakashatsi bwo kurwanya kanseri.Inkomoko ya Pyrazolo [3,4-c] inkomoko ya pyridine yerekanye ibikorwa bitanga ikizere cyo kurwanya ikwirakwizwa ry’ubwoko butandukanye bwa kanseri.Ubushobozi bwabo bwo guhagarika inzira zihariye zigira uruhare mu mikurire y’ibibyimba no kubaho bituma bashobora kuba abakandida mu iterambere ry’imiti irwanya kanseri.Iyindi nyigisho irakenewe kugirango hamenyekane uburyo bwibikorwa no gusuzuma imikorere yikigo mugihe cyibanze nubuvuzi.Ikindi kandi, iyi nteruro yerekanye amasezerano nkumuntu ushobora kurwanya antibacterial.Yerekanye ibikorwa birwanya amoko atandukanye ya bagiteri, harimo na Gram-positif na Gram-mbi.Ubushobozi bwo kwibasira amoko menshi bwerekana ubushobozi bwabwo mukurwanya bagiteri zidakira imiti, zimaze kuba ikibazo cyubuzima ku isi.Ubundi bushakashatsi burasabwa gukora ubushakashatsi ku buryo bukora no gusuzuma akamaro kabwo mu kurwanya indwara ziterwa na bagiteri.Ikindi kandi, pyrazolo [3,4-c] ibikomoka kuri pyridine, harimo n'uru ruganda, byagaragaje ubushobozi mu kuvura indwara ziterwa na autoimmune.Gutwika bigira uruhare runini mubihe bitandukanye nka rubagimpande ya rubagimpande na psoriasis.Ibikomokaho byagaragaje imiti igabanya ubukana muguhindura inzira zihariye zigira uruhare mugusubiza.Ibi birerekana ubushobozi bwabo nkibikoresho byo kuvura indwara zidakira hamwe nindwara ziterwa nayo.Ikindi kandi, iyi nteruro yerekanye ibikorwa muri sisitemu yo hagati (CNS).Hakozwe ubushakashatsi ku bushobozi bwayo mu ndwara zifata ubwonko nk'indwara ya Alzheimer n'indwara ya Parkinson.Uru ruganda rushobora guhindura reseptor na enzymes zigira uruhare mu gutera indwara, birashoboka ko bitanga ingaruka za neuroprotective.Nyamara, ubushakashatsi buracyakenewe kugirango dusobanukirwe neza nuburyo bwibikorwa no gusuzuma akamaro kayo mukuvura izo ndwara zitoroshye. Muri make, 1- (4-Methoxyphenyl) -7-oxo-6- [4- (2-oxopiperidin-1- yl) phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo , hamwe na CNS ihungabana.Ubushobozi bwayo buri mubushobozi bwayo bwo guhitamo inzira zihariye hamwe na reseptors zifite uruhare muri ibi bihe.Nyamara, ubushakashatsi niperereza birakenewe kugirango tumenye neza ubushobozi bwayo, tunonosore imitungo yabyo, kandi dusuzume umutekano wacyo nibikorwa byubuvuzi.