Ibicuruzwa

1-. , cyane cyane mu kuvumbura ibiyobyabwenge.Kubaho kwa hydroxymethylpyridinyl byerekana imikoranire ishobora kuba ifite intego yibinyabuzima, nka enzymes cyangwa reseptors.Abashinzwe imiti barashobora guhindura imiterere yuru ruganda kugirango barusheho guhuza no guhitamo intego yibinyabuzima bifuza.Muguhindura imitekerereze ya fenyl na piperazine, abashakashatsi barashobora guhuza neza imiterere yumubiri wa fiziki ya chimique na pharmacokinetics, ibyo bikaba bishobora gutuma ibiyobyabwenge bigenda neza kandi bikagabanya ingaruka zitifuzwa. Ubundi buryo bushobora gukoreshwa 1- (3-Hydroxymethylpyridin-2-yl) -4 -methyl-2-fenylpiperazine iri mubijyanye na neuropharmacology.Imiterere yuru ruganda yerekana imikoranire ishoboka niyakirwa muri sisitemu yo hagati yububiko, bishobora gutera ingaruka zo kuvura indwara zifata ubwonko.Kurugero, birashobora gushakishwa nkumukandida wo guhindura neurotransmission mubihe nko guhangayika, kwiheba, cyangwa sikizofreniya.Abashakashatsi barashobora gukora iperereza kubikorwa byuburyo bwikigo kandi bagakora ubushakashatsi bwibanze nubuvuzi kugirango basuzume ubushobozi bwabwo bwo kuvura.Ikindi kandi, imiterere yuru ruganda rushobora gutuma ikwirakwizwa no gutanga imiti.Amatsinda ya hydrophobique phenyl na methyl yerekana ubushobozi bwo kwambuka lipide, bikabasha kwibasira imisemburo idasanzwe cyangwa inzira.Uyu mutungo ufite akamaro ko guteza imbere ibiyobyabwenge bigomba kwinjira mu ngirabuzimafatizo no kugira ingaruka ku ntego zihariye.Muguhindura imiterere yikigo, imiti yimiti irashobora kongera bioavailability yayo, igatezimbere ituze, kandi igashyiraho ingamba zifatika zo gutanga imiti. Ni ngombwa kumenya ko gukoresha 1- (3-Hydroxymethylpyridin-2-yl) -4-methyl-2 -phenylpiperazine muri izi porogaramu zishobora gusaba isuzumabumenyi rikomeye n’ubuvuzi kugira ngo umutekano, imikorere, hamwe na dosiye ikwiye.Ubushakashatsi bwagutse bwa farumasi nuburozi burakenewe kugirango dusobanukirwe ingaruka zabyo muburyo butandukanye bwibinyabuzima no kumenya ingaruka zose zishobora kubaho.Mu ncamake, 1- (3-Hydroxymethylpyridin-2-yl) -4-methyl-2-fenylpiperazine nuruvange rufite ibintu bitandukanye. ibishoboka mubishobora kuvura imiti no guteza imbere ibiyobyabwenge.Ifite amasezerano yo gutegura imiti mishya, cyane cyane mubice bya neuropharmacology no gutanga ibiyobyabwenge.Ubundi bushakashatsi burakenewe kugirango hamenyekane imikoranire yihariye, uburyo bwibikorwa, hamwe nubushobozi bwo kuvura, butange inzira yiterambere ryokuvura indwara nindwara zitandukanye.