Ibicuruzwa

1-. ya CPPMP iri mu kuvura indwara zifata ubwonko.Kubaho kwa carboxypyridyl byerekana ubushobozi bwayo bwo gukorana na reseptor yihariye ya neuronal muri sisitemu yo hagati.Kwibanda kuri aba reseptors birashobora guhindura neurotransmission, birashobora gutuma umuntu agira ingaruka zo kuvura mubihe nko kwiheba, guhangayika, cyangwa indwara ya neurodegenerative disorders.Ubundi bushakashatsi burakenewe kugira ngo hamenyekane imikoranire yihariye ya reseptor hamwe nuburyo bwibikorwa bya CPPMP hagamijwe kunoza ubushobozi bwayo nkumuti uvura indwara zifata ubwonko.Abashinzwe imiti barashobora guhindura ibice bitandukanye byimiterere yabyo kugirango bongere imiti ya farumasi cyangwa intego yinzira yibinyabuzima.Mugutezimbere imiterere ya CPPMP, abashakashatsi barashobora gukora ibiyikomokaho hamwe no guhitamo neza, imbaraga, hamwe numwirondoro wumutekano, bigatuma baba abakandida babereye imiti yibasira indwara zitandukanye.Ikindi kandi, amatsinda ya fenil na methyl ya CPPMP atanga hydrophobique, ishobora kuba nziza mugutezimbere ibiyobyabwenge bishobora kwambuka selile selile kandi igere ku ntego zidasanzwe.Iyi mikorere irashobora gukoreshwa mugushushanya imiti yubuvanganzo yibanda cyane cyane imisemburo yo mu nda cyangwa inzira, itanga amahirwe yo kwivuza mu ndwara nka kanseri cyangwa indwara ziterwa na metabolike. Byongeye kandi, imiterere yihariye yimiterere ya CPPMP ituma habaho iterambere rya prodrugs cyangwa uburyo bwo gutanga ibiyobyabwenge. .Muguhindura itsinda ryayo rya carboxypyridyl, uruganda rushobora kuba rwarakozwe kugirango rube ruhamye cyangwa rufite ubumara buke muburyo bwa kavukire, mugihe rutanga neza ibiyobyabwenge bikora kurubuga rwifuzwa.Ihinduka nkiryo rishobora kuzamura bioavailability hamwe nubuvuzi bwiza bwikigo.Nkwiye kumenya ko ikoreshwa rya CPPMP muribi bisabwa rishobora kuba impimbano kandi bisaba ubushakashatsi niterambere ryambere mbere yo gukoreshwa bifatika.Byongeye kandi, imikoreshereze yose ya CPPMP yakenera gukurikiza protocole yumutekano n’amabwiriza kugira ngo habeho gukemura neza no kugabanya ingaruka. Mu gusoza, 1- (3-Carboxypyrid-2-yl) -2-fenyl-4-methyl-piperazine, cyangwa CPPMP , ifite amasezerano kubisabwa bitandukanye muri chimie chimique.Imiterere yacyo igoye itanga amahirwe yo guteza imbere imiti ivura indwara zifata ubwonko, kimwe nibiyobyabwenge byibasira indwara zitandukanye.Hamwe nubushakashatsi bunoze kandi bunoze, CPPMP ifite ubushobozi bwo gutanga umusanzu ukomeye mubijyanye n'ubuvuzi no kuzamura umusaruro w'abarwayi.