β-Alanine CAS: 107-95-9 Ifu yera ya kristaline
| Umubare wa Cataloge | XD90324 |
| izina RY'IGICURUZWA | Alanine |
| URUBANZA | 107-95-9 |
| Inzira ya molekulari | C3H7NO2 |
| Uburemere bwa molekile | 89.09 |
| Ibisobanuro birambuye | Ibidukikije |
| Amategeko agenga ibiciro | 29224920 |
Kugaragaza ibicuruzwa
| Kugaragara | Ifu ya kirisiti yera |
| Suzuma | 99% |
Indwara y’umwijima idafite inzoga (NAFLD) ifite ubwoko butandukanye bw’indwara kuva kuri steatose yoroheje irangwa no kugumana bidasanzwe lipide mu ngirangingo z’umwijima kugeza kuri steatohepatitis (NASH) yerekana kwirundanya kw'amavuta, gutwika, ballon no kwangirika kwa hepatocytes, na fibrosis.Ubwanyuma, steatohepatitis irashobora kuviramo umwijima cirrhose na kanseri ya hepatocellular.Muri ubu bushakashatsi twasesenguye ubwoko butatu bwimbeba, A / J, C57BL / 6J, na PWD / PhJ, bwerekana impamyabumenyi zitandukanye za steatohepatitis mugihe utanzwe na 3,5-diethoxycarbonyl -1,4-dihydrocollidine (DDC) irimo indyo.Isesengura ryerekana imiterere ya RNA-Seq, isesengura rya poroteyine hamwe n’imiterere ya metabolike byakoreshejwe kugira ngo hamenyekane genes / poroteyine zitandukanye ndetse n’urwego rwa metabolite rwerekana urugero rw’umwijima w’imbeba nyuma yo kuvura DDC.Isesengura ry'inzira ryagaragaje guhindura aside arachidonic (AA) na S-adenosylmethionine (SAMe) metabolism ku zindi nzira.Kugira ngo dusobanukirwe nimpinduka ziterwa na arachidonic aci d metabolism ukurikije imiterere yindwara zerekana imiterere ya kinetic yiyi nzira yatejwe imbere kandi itezimbere ukurikije urwego rwa metabolite.Icyakurikiyeho, icyitegererezo cyakoreshejwe mu kwiga ku ngaruka za silico ziterwa n’ibiyobyabwenge bishobora kwanduzwa na steatohepatitis.Twabonye ko metabolism ya AA / eicosanoid ihindagurika cyane mu mbeba zatewe na DDC dukoresheje uburyo bwo kugerageza no mu buryo bwa silico.Isesengura ryacu ryinzira ya AA / eicosanoid ryerekana ko aside 5-hydroxyeicosatetraenoic aside (5-HETE), 15-hydroxyeicosatetraenoic aside (15-HETE) na prostaglandine D2 (PGD2) ihungabanijwe nimbeba za DDC.Twongeye kwerekana ko icyitegererezo gifite imbaraga gishobora gukoreshwa muburyo bwiza bwo guhanura impinduka zishingiye ku mibare ishingiye ku mibare ijyanye n'indwara.Byongeye kandi, SAMe metabolism yagaragaye ko ihungabanye kubera kuvura DDC.Imirasire myinshi kimwe na metabolite yiyi module yerekana itandukaniro hagati ya A / J na C57BL / 6J kuruhande rumwe na PWD / PhJ kurundi ruhande.
