Ibicuruzwa

(αS, 3S) -α - [(tert-Butyloxycarbonyl) amin] chimie.Boc-Amino acide methyl ester ikora nkuburyo bukingiwe bwa aside amine, aho itsinda rya Boc (tert-butyloxycarbonyl) rikoreshwa mukurinda itsinda rya amino mugihe cyo kwitwara.Uru ruganda rukoreshwa cyane cyane muri synthesis ya peptide kugirango yinjize aside amine yihariye muminyururu ya peptide.Peptide ni iminyururu ngufi ya acide amine igira uruhare runini muri sisitemu y’ibinyabuzima.Bagira uruhare mubikorwa bitandukanye nko gutangaza ibimenyetso, kugenzura imisemburo, no gushyigikira imiterere.Peptide synthesis ikubiyemo guteranya intambwe ya acide ya amino kugirango ikore urutonde rwihariye rwigana peptide karemano cyangwa irema ibintu bishya bifite imitungo yifuzwa.Boc-Amino acide methyl ester ikunze gukoreshwa nkibice byubaka muri synthesis ya peptide ikomeye (SPPS), aribyo bumwe muburyo bukoreshwa cyane mukubaka peptide.Muri SPPS, urunigi rwa peptide rushyirwa muburyo butambutse ku nkunga ihamye, mubisanzwe ukoresheje aside amine ikomoka hamwe nitsinda ririnda by'agateganyo.Acide ya Boc-Amino methyl ester nigikoresho cyiza cyo gutangirira kuri SPPS kubera ituze, ihindagurika, kandi igahuzwa nizindi reagent ya peptide. Mugihe cya peptide, peptide ya Boc-Amino methyl ester yongerwa mumurongo wa peptide ukura binyuze muburyo bwo guhuza amide.Itsinda ririnda Boc ririnda ingaruka zitifuzwa kandi ryemeza guhuza aside amine kumurongo wa peptide.Urutonde rwifuzwa rumaze kugerwaho, itsinda rya Boc rivanwaho mubihe byoroheje, bikagaragaza itsinda rya amino ryubuntu kugirango rihindurwe cyangwa riranga peptide. Usibye synthesis ya peptide, methyl ester ya Boc-Amino irashobora no gukoreshwa mugutegura imiti itandukanye. abahuza, ubuhinzi-mwimerere, nibindi bintu kama.Gukoresha byoroshye, gutekana, no guhuza nuburyo busanzwe bwo kubyitwaramo bituma bihinduka inyubako zinyuranye zo guhuza ibinyabuzima.Muri rusange, aside ya Boc-Amino methyl ester nigikoresho cyingirakamaro muri synthesis ya peptide na chimie organic.Uruhare rwarwo nkuburyo bukingiwe bwa acide aminide ituma guteranya neza iminyururu ya peptide no gushiraho imiterere itandukanye ya peptide yubushakashatsi, kuvumbura ibiyobyabwenge, hamwe nubuvuzi bukoreshwa.